Hypoxia inducible factor 1 ( HIF-1), a nuclear protein with transcription activity, can make the body produce adaptive response to hypoxia/ ischemia by binding to target gene, transcription and post-transcriptional control. 缺氧诱导因子-1(HIF-1)是一种具有转录活性的核蛋白,能与靶基因结合并通过转录和转录后调控,使机体对缺氧、缺血产生适应性反应。
The methods to reverse cardiac remodeling was still deficiency in nowadays, people in the previous researches always focused on the post-translational regulation of neurohumor and signal transduction pathway in the pathogenesis of cardiac remodeling, while the research of the mechanisms of post-transcriptional control was not so much. 目前逆转心脏重构的手段仍较缺乏,之前的研究主要集中在心脏重构发病的神经体液和信号转导通路的翻译后调控,对于转录后调控的机制研究较少。
RNA interference ( RNAi) can effectively silence the expression of specific gene on post-transcriptional level, which is one of the most important signal channels in Genetic control network and is widely used in cancer therapy. RNA干扰(RNAinterference,RNAi)是指在转录后水平有效沉默特异性基因的表达,是生物遗传控制网络中的重要通路之一,已被广泛用于肿瘤的治疗研究。